Summary Table: Affinity of cannabinoids to CB1 & CB2
- waksmanya
- Sep 29, 2024
- 1 min read

The affinity of cannabinoids to CB1R & CB2R - The huge fluctuations in results are due to different assay conditions in different laboratories, using normal cells or transfected cells that display these receptors.
Structure-Activity Relationships [SAR] Studies
SAR of classical cannabinoids (left) major pharmacophores of classical cannabinoids, and common regions of functionalization and analog synthesis; (right) dibenzopyran numbering of Δ9-THC.
Elongation of the alkyl side chain increases THC's affinity.
However, shortening of the alkyl side chain in THCV does not affect the affinity of the molecule to CB1 & CB2 receptors.
Another way to describe CBD's structure:
The alkyl side chain (C=C) in the open ring pushes the C (top left) ring away to the top of the molecule, therefore CBD does not bind eCB receptors as does THC.
Composition of pCBs in different Hashish samples from various locations
Lebanese Hash contains a lot of CBD.
South African Hash contains a lot of THC.
Afghan Hash contains a lot of THC & CBD.
Burmese Hash contains a lot of CBN.
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