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Summary Table: Affinity of cannabinoids to CB1 & CB2

  • waksmanya
  • Sep 29, 2024
  • 1 min read

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The affinity of cannabinoids to CB1R & CB2R - The huge fluctuations in results are due to different assay conditions in different laboratories, using normal cells or transfected cells that display these receptors.


Structure-Activity Relationships [SAR] Studies

SAR of classical cannabinoids (left) major pharmacophores of classical cannabinoids, and common regions of functionalization and analog synthesis; (right) dibenzopyran numbering of Δ9-THC.

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Elongation of the alkyl side chain increases THC's affinity.

However, shortening of the alkyl side chain in THCV does not affect the affinity of the molecule to CB1 & CB2 receptors.


Another way to describe CBD's structure:

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The alkyl side chain (C=C) in the open ring pushes the C (top left) ring away to the top of the molecule, therefore CBD does not bind eCB receptors as does THC.


Composition of pCBs in different Hashish samples from various locations

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Lebanese Hash contains a lot of CBD.

South African Hash contains a lot of THC.

Afghan Hash contains a lot of THC & CBD.

Burmese Hash contains a lot of CBN.

 
 
 

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