Cannabinoid Research
Origin of Cannabis
The Endocannabinoid System
Major Phytocannabinoids
Minor Phytocannabinoids
Organic Medical Cannabis
Effect of Light on pCBs
Cannabinoid-Honey
Genetic susceptibility to THC & CBD
Synthetic Cannabinoids
Research proposals
Disclosure:
In 1996 when we discovered the anti-inflammatory action of cannabidiol (CBD), the late Prof. Raphael Meshulam, Prof. Esther Shohami, Prof. Ruth Galili and Anochi, in the Natural Materials Research Department of the Ein Kerem School of Pharmacy, we thought that research Medical use of this phytocannabinoid - lacking the psychoactive activity - will help to recognize the medicinal value of the entire cannabis plant.
Gradually, the THC was presented as a dangerous and unwanted component of the plant, it became clear that adding CBD to the treatment of THC prevents the development of unwanted side effects such as psychosis and the company "Tikhon Olam" developed the strain "Avidekel" which is a medical cannabis rich in CBD that contains little THC. In this way, the foundations were laid for the writing of the HIKR's "Green Book", which includes tables of the concentrations of THC and CBD as a treatment for various diseases.
However, after two decades, it is time to discuss the medical value of isolated THC as well. Hereditary test in a saliva sample for the presence of point mutations In genes that code for important target proteins, you can warn against the development of an unwanted reaction to THC.
Table of contents
All articles can be downloaded for free - by clicking on the article title
Origin of Cannabis:
Searching for the extinct, common ancestor of Humulus & Cannabis plants
Cannabis Systematics at the Levels of Family, Genus, and Species. John M. McPartland
The Endocannabinoid System:
review: Synergistic relationships between the endocannabinoid and the opiod systems
Summary Table: Affinity of cannabinoids to CB1 & CB2
Fatty Acids Binding Proteins – Cannabinoids - Cancer
Major Phytocannabinoids:
The effects of Cannabigerol CBG on Muscle, Joint & Bone
review - Tetrahydrocannabinol (THC)
Mode of action & therapeutic effects of cannabidiol [CBD]
Mode of action & therapeutic effects of cannabidiol [CBD] - ppt
CBD Innovative approaches in stress management
Alzheimer Dementia - CBD As A Natural Treatment For Neurological Disorders
Cannabichromene (CBC) Mode of Action & Therapeutic Effects
Minor Phytocannabinoids:
Minor Cannabinoids - general overview
Organic Medical Cannabis:
Early Israeli Medicinal Cannabis Research
Executive Summary & Investors Review Roadmap for the German Medicinal Cannabis Project
Types of cannabis concentrates
Environmental study that finds new pCBs - Ozonation of THCA & THC
Advantages of Aeroponic Growth for Cannabis
Effect of Light on pCBs:
review - Effect of Light on pCBs
Therapeutic potential of cannabinoids for human skin disorders and wound healing
Cannabinoid-Honey:
Water-soluble phytocannabinoids produced by Honeybees
Metabolism of Cannabis compounds by the Honey Bee
Genetic susceptibility to THC & CBD:
Genetic susceptibility to THC & CBD - full review
Genetic susceptibility to THC & CBD - Development of Diagnostic Tool
Synthetic Cannabinoids:
Research proposals:
Methods to produce more CBDA And less THCA in Industrial Hemp. Ozonization & Hydrogenation of pCBs
About the results of my studies at "Cannabics" - 2021
September 24, 2021 ·
A new series of tests conducted in Israel have shown that both CBC and CBG exhibit anti-tumour properties on cancer cells.
The tests have shown that the cannabinoids CBC (Cannabichromene) and CBG (Cannabigerol) both exhibit anti-tumour properties after being tested on human Gastrointestinal Cancer Cells.
CBC is an additional non-psychoactive cannabinoid and is one of the naturally occurring phyto-cannabinoids, bearing a host of potential positive therapeutic qualities and may promote antimicrobial, anti‐inflammatory, analgesic, and neurogenesis activity. It is particularly found in younger cannabis plants, albeit in small quantities.
CBC and CBG were both shown to induce significantly higher rates of necrosis in these cancer cells compared to other cannabinoids.
Dr Yaakov Waksman, the company’s head of cannabidiol research, said: “My working assumption is that these results show that a correlation may exist between a cannabinoid’s Topological Polar Surface Area (TPSA) value and its ability to induce anti-tumour activity, diminishing cancer cell’s viability rates.
“CBC and CBG, as neutral cannabinoids, were both found to have a TPSA value which allows the cannabinoid molecule to penetrate a cancer cell’s membrane, whereas their acidic form (CBCA and CBGA) – do not. This could explain the difference in anti-tumour activity rates demonstrated”.Dr Eyal Ballan, CTO and Co-Founder, added: “Gastrointestinal cancers are amongst the leading and most wide-spread causes of cancer-related deaths worldwide. We are intrigued by the results we have obtained in the lab, and our aim is to consider placing an emphasis on this organ system, and to further explore the differential anti-tumour properties of cannabinoids.
from: “The Wacky World of Florida Cannabis”